Hypogonadism in HIV-1-infected men is common and does not resolve during antiretroviral therapy

Wunder, DM; Bersinger, NA; Fux, CA; Mueller, NJ; Hirschel, B; Cavassini, M; Elzi, L; Schmid, P; Bernasconi, E; Mueller, B; Furrer, H; HIV Cohort Study, Swiss (2007). Hypogonadism in HIV-1-infected men is common and does not resolve during antiretroviral therapy. Antiviral therapy, 12(2), pp. 261-5. London: International Medical Press

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OBJECTIVES: To assess the prevalence of abnormal testosterone and gonadotropin values in HIV-infected men before and after 2 years of combination antiretroviral therapy (cART). DESIGN: Multicentre cohort of HIV-infected adults. METHODS: We identified 139 Caucasian antiretroviral-naive male patients who started zidovudine/ lamivudine-based cART that was virologically successful over a 2 year period. Ninety-seven were randomly chosen and plasma hormone determinations of free testosterone (fT) and luteinizing hormone (LH) at baseline and after 2 years of cART were evaluated. RESULTS: At baseline 68 patients (70%) had subnormal fT levels. In these, LH levels were low in 44%, normal in 47% and high in 9%. There was a trend for an association between lower CD4+ T-cell counts and hypogonadism. Most participants had normal FSH levels. No significant changes of fT, LH and FSH levels were observed after 2 years of cART. CONCLUSIONS: Low fT levels, mainly with normal or low LH levels and thus indicating secondary hypogonadism, are found in the majority of HIV-infected men and do not resolve during 2 years of successful cART.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Wunder, Dorothea; Bersinger, Nick A.; Fux, Christoph Andreas and Furrer, Hansjakob

ISSN:

1359-6535

ISBN:

17503668

Publisher:

International Medical Press

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:59

Last Modified:

21 Jan 2015 11:14

PubMed ID:

17503668

Web of Science ID:

000247111500013

URI:

https://boris.unibe.ch/id/eprint/25681 (FactScience: 60460)

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