Betsch, BY; Eggli, S; Siebenrock, KA; Täuber, MG; Mühlemann, K (2008). Treatment of joint prosthesis infection in accordance with current recommendations improves outcome. Clinical infectious diseases, 46(8), pp. 1221-6. Cary, N.C.: The University of Chicago Press 10.1086/529436
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BACKGROUND: Recently recommended treatment modalities for prosthetic joint infection (PJI) were evaluated. METHODS: A retrospective cohort analysis of 68 patients with PJI of hip or knee who were treated from 1995 through 2004 was conducted at the University Hospital Bern (Bern, Switzerland). RESULTS: A 2-stage exchange was the most frequent (75.0%) surgical strategy, followed by retention and debridement (17.6%), 1-stage exchange (5.9%), and resection arthroplasty or suppressive antimicrobial treatment (1.5%). The chosen strategy was in 88% agreement with the recommendations. Adherence was only 17% for retention and debridement and was 0% for 1-stage exchange. Most PJIs (84%) were treated with an adequate or partially adequate antimicrobial regimen. Recurrence-free survival was observed in 51.5% of PJI episodes after 24 months of follow-up. The risk of treatment failure was significantly higher for PJI treated with a surgical strategy other than that recommended (hazard ratio, 2.34; 95% confidence interval, 1.10-4.70; P = .01) and for PJIs treated with antibiotics not corresponding to recommendations (hazard ratio, 3.45; confidence interval, 1.50-7.60; P = .002). Other risk factors associated with lack of healing were a high infection score at the time of diagnosis (hazard ratio, 1.29; 95% confidence interval, 1.10-1.40; P < .001) and presence of a sinus tract (hazard ratio, 2.35; 95% confidence interval, 1.10-5.0; P = .02). CONCLUSIONS: Our study demonstrates the value of current treatment recommendations. Inappropriate choice of conservative surgical strategies (such as debridement and retention) and inadequate antibiotic treatment are associated with failure.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology 04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Orthopaedic Surgery |
UniBE Contributor: |
Betsch, Belinda Yasmin, Eggli, Stefan, Siebenrock, Klaus-Arno, Täuber, Martin G., Mühlemann, Kathrin |
ISSN: |
1058-4838 |
ISBN: |
18444859 |
Publisher: |
The University of Chicago Press |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:59 |
Last Modified: |
05 Dec 2022 14:18 |
Publisher DOI: |
10.1086/529436 |
PubMed ID: |
18444859 |
Web of Science ID: |
000254754400016 |
BORIS DOI: |
10.7892/boris.25696 |
URI: |
https://boris.unibe.ch/id/eprint/25696 (FactScience: 60738) |
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