Kinematic improvement following Botulinum Toxin-A injection in upper-limb spasticity due to stroke

Fridman, Esteban A; Crespo, Marcos; Gomez Argüello, Santiago; Degue, Lorena; Villarreal, Mirta; Bohlhalter, Stephan; Wheaton, Lewis; Hallett, Mark (2010). Kinematic improvement following Botulinum Toxin-A injection in upper-limb spasticity due to stroke. Journal of neurology, neurosurgery and psychiatry, 81(4), pp. 423-7. London: BMJ Publishing Group 10.1136/jnnp.2009.188052

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Background Focal spasticity is a significant motor disorder following stroke, and Botulinum Toxin Type-A (BoNT-A) is a useful treatment for this. The authors evaluated kinematic modifications induced by spasticity, and whether or not there is any improvement following injection of BoNT-A. Methods Eight patients with stroke with upper-limb spasticity, showing a flexor pattern, were evaluated using kinematics before and after focal treatment with BoNT-A. A group of sex- and age-matched normal volunteers acted as a control group. Results Repeated-measures ANOVA showed that patients with stroke performed more slowly than the control group. Following treatment with BoNT-A, there was a significant improvement in kinematics in patients with stroke, while in the control group, performance remained unchanged. Conclusions Focal treatment of spasticity with BoNT-A leads to an adaptive change in the upper limb of patients with spastic stroke.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Bohlhalter, Stephan




BMJ Publishing Group




Factscience Import

Date Deposited:

04 Oct 2013 14:07

Last Modified:

05 Dec 2022 14:00

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URI: (FactScience: 197144)

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