Expression of proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta in the brain during experimental group B streptococcal meningitis

Kim, YS; Honkaniemi, J; Sharp, FR; Täuber, MG (2004). Expression of proinflammatory cytokines tumor necrosis factor-alpha and interleukin-1beta in the brain during experimental group B streptococcal meningitis. Molecular brain research, 128(1), pp. 95-102. Amsterdam: Elsevier 10.1016/j.molbrainres.2004.06.009

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We performed mRNA in situ hybridization for TNF-alpha and IL-1beta from infant rats with group B streptococcal meningitis. Induction of both cytokines was seen in the ependyma and the meninges at 4 h. Both cytokines were expressed in the brain parenchyma at 12 h. Induction of IL-1beta mRNA was seen in vessels within the brain cortex. Neutrophilic infiltrate at all time points examined was minimal and could not account for the observed cytokine expression.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Täuber, Martin G.

ISSN:

0169-328X

ISBN:

15337322

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:00

Last Modified:

06 Dec 2013 13:50

Publisher DOI:

10.1016/j.molbrainres.2004.06.009

PubMed ID:

15337322

Web of Science ID:

000223878900011

URI:

https://boris.unibe.ch/id/eprint/25716 (FactScience: 60798)

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