Cefepime is efficacious against penicillin- and quinolone-resistant pneumococci in experimental meningitis

Cottagnoud, P; Acosta, F; Cottagnoud, M; Täuber, MG (2002). Cefepime is efficacious against penicillin- and quinolone-resistant pneumococci in experimental meningitis. Journal of antimicrobial chemotherapy, 49(2), pp. 327-30. Oxford: Oxford University Press 10.1093/jac/49.2.327

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In experimental rabbit meningitis, cefepime given at a dose of 100 mg/kg was associated with concentrations in the cerebrospinal fluid of between 5.3 and 10 mg/L and a bactericidal activity of -0.61 +/- 0.24 Delta log(10) cfu/mL x h, similar to the standard regimen of ceftriaxone combined with vancomycin (-0.58 +/- 0.14 Delta log(10) cfu/mL x h) in the treatment of meningitis due to a penicillin- and quinolone-resistant pneumococcal mutant strain (MIC 4 mg/L). Compared with the penicillin-resistant parental strain, the penicillin- and quinolone-resistant mutant was killed more slowly by cefepime and ceftriaxone in time-killing assays in vitro over 8 h.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Täuber, Martin G.

ISSN:

0305-7453

ISBN:

11815575

Publisher:

Oxford University Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:00

Last Modified:

28 Oct 2019 16:28

Publisher DOI:

10.1093/jac/49.2.327

PubMed ID:

11815575

Web of Science ID:

000173960000015

BORIS DOI:

10.7892/boris.25734

URI:

https://boris.unibe.ch/id/eprint/25734 (FactScience: 60836)

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