Gentamicin increases the efficacy of vancomycin against penicillin-resistant pneumococci in the rabbit meningitis model

Cottagnoud, P; Gerber, CM; Cottagnoud, M; Täuber, MG (2002). Gentamicin increases the efficacy of vancomycin against penicillin-resistant pneumococci in the rabbit meningitis model. Antimicrobial agents and chemotherapy, 46(1), pp. 188-90. Washington, D.C.: American Society for Microbiology 10.1128/AAC.46.1.188-190.2002

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In experimental meningitis a single dose of gentamicin (10 mg/kg of body weight) led to gentamicin levels in around cerebrospinal fluid (CSF) of 4 mg/liter for 4 h, decreasing slowly to 2 mg/liter 4 h later. The CSF penetration of gentamicin ranged around 27%, calculated by comparison of areas under the curve (AUC in serum/AUC in CSF). Gentamicin monotherapy (-1.24 log(10) CFU/ml) was inferior to vancomycin monotherapy (-2.54 log(10) CFU/ml) over 8 h against penicillin-resistant pneumococci. However, the combination of vancomycin with gentamicin was significantly superior (-4.48 log(10) CFU/ml) compared to either monotherapy alone. The synergistic activity of vancomycin combined with gentamicin was also demonstrated in vitro in time-kill assays.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Täuber, Martin G.

ISSN:

0066-4804

ISBN:

11751132

Publisher:

American Society for Microbiology

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:00

Last Modified:

04 May 2014 23:17

Publisher DOI:

10.1128/AAC.46.1.188-190.2002

PubMed ID:

11751132

Web of Science ID:

000172867600029

URI:

https://boris.unibe.ch/id/eprint/25735 (FactScience: 60838)

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