Linezolid against penicillin-sensitive and -resistant pneumococci in the rabbit meningitis model

Cottagnoud, P; Gerber, CM; Acosta, F; Cottagnoud, M; Neftel, K; Täuber, MG (2000). Linezolid against penicillin-sensitive and -resistant pneumococci in the rabbit meningitis model. Journal of antimicrobial chemotherapy, 46(6), pp. 981-5. Oxford: Oxford University Press 10.1093/jac/46.6.981

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Linezolid, a new oxazolidinone antibiotic, showed good penetration (38+/-4%) into the meninges of rabbits with levels in the CSF ranging from 9.5 to 1.8 mg/L after two i.v. injections (20 mg/kg). Linezolid was clearly less effective than ceftriaxone against a penicillin-sensitive pneumococcal strain. Against a penicillin-resistant strain, linezolid had slightly inferior killing rates compared with the standard regimen (ceftriaxone combined with vancomycin). In vitro, linezolid was marginally bactericidal at concentrations above the MIC (5 x and 10 x MIC).

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Täuber, Martin G.

ISSN:

0305-7453

ISBN:

11102418

Publisher:

Oxford University Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:00

Last Modified:

29 Oct 2019 02:45

Publisher DOI:

10.1093/jac/46.6.981

PubMed ID:

11102418

Web of Science ID:

000166047000017

BORIS DOI:

10.7892/boris.25745

URI:

https://boris.unibe.ch/id/eprint/25745 (FactScience: 60858)

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