Grepafloxacin against penicillin-resistant pneumococci in the rabbit meningitis model

Gerber, CM; Tovar, L; Cottagnoud, M; Neftel, KA; Täuber, MG; Cottagnoud, P (2000). Grepafloxacin against penicillin-resistant pneumococci in the rabbit meningitis model. Journal of antimicrobial chemotherapy, 46(2), pp. 249-53. Oxford: Oxford University Press 10.1093/jac/46.2.249

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Grepafloxacin, a new fluoroquinolone, produced bactericidal activity comparable to that of vancomycin and ceftriaxone in the treatment in rabbits of meningitis caused by a pneumococcal strain highly resistant to penicillin (MIC 4 mg/L) (triangle uplog(10) cfu/mL*h for grepafloxacin, -0.32 +/- 0.15; dose, 15 mg/kg iv; triangle uplog(10) cfu/mL*h for vancomycin, -0.39 +/- 0.18; dose, 2 x 20 mg/kg iv; triangle uplog(10) cfu/mL*h for ceftriaxone, -0.32 +/- 0. 12; dose, 125 mg/kg iv). Higher doses of grepafloxacin (30 mg/kg and 2 x 50 mg/kg) did not improve the killing rates. The combination of grepafloxacin with vancomycin was not significantly superior to monotherapies (P > 0.05). In vitro, grepafloxacin was bactericidal at concentrations above the MIC. Using concentrations around the MIC, addition of vancomycin to grepafloxacin showed synergic activity.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Täuber, Martin G.

ISSN:

0305-7453

ISBN:

10933648

Publisher:

Oxford University Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:00

Last Modified:

28 Oct 2019 00:50

Publisher DOI:

10.1093/jac/46.2.249

PubMed ID:

10933648

Web of Science ID:

000089309900013

BORIS DOI:

10.7892/boris.25746

URI:

https://boris.unibe.ch/id/eprint/25746 (FactScience: 60861)

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