Effects of clinically used antioxidants in experimental pneumococcal meningitis

Auer, Marc; Pfister, Luz-Andrea; Leppert, David; Täuber, Martin G.; Leib, Stephen L. (2000). Effects of clinically used antioxidants in experimental pneumococcal meningitis. Journal of infectious diseases, 182(1), pp. 347-350. Cary, N.C.: The University of Chicago Press 10.1086/315658

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Reactive oxygen intermediates mediate brain injury in bacterial meningitis. Several antioxidant drugs are clinically available, including N-acetylcysteine (NAC), deferoxamine (DFO), and trylizad-mesylate (TLM). The present study evaluated whether these antioxidants are beneficial in a model of pneumococcal meningitis. Eleven-day-old rats were infected intracisternally with Streptococcus pneumoniae and randomized to intraperitoneal treatment every 8 h with NAC (200 mg/kg), DFO (100 mg/kg), TLM (10 mg/kg), or saline (250 microL). TLM-treated animals showed a significantly reduced mortality compared with controls (P<.03). Meningitis led to extensive cortical injury at 22+/-2.2 h after infection (median, 14. 6% of cortex; range, 0-61.1%). Injury was significantly (P<.01) reduced to 1.1% (range, 0-34.6%) by NAC, to 2.3% (range, 0-19.6%) by DFO, and to 0.2% (range, 0-36.9%) by TLM (the difference was not significant among the 3 groups). None of the drugs reduced hippocampal injury. Thus, several clinically used antioxidants reduced cortical injury in experimental pneumococcal meningitis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Täuber, Martin G. and Leib, Stephen

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0022-1899

ISBN:

10882622

Publisher:

The University of Chicago Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:00

Last Modified:

27 Apr 2018 09:39

Publisher DOI:

10.1086/315658

PubMed ID:

10882622

Web of Science ID:

000088522300049

BORIS DOI:

10.7892/boris.25749

URI:

https://boris.unibe.ch/id/eprint/25749 (FactScience: 60867)

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