Amino acids in cerebrospinal and brain interstitial fluid in experimental pneumococcal meningitis

Guerra-Romero, L; Tureen, JH; Fournier, MA; Makrides, V; Täuber, MG (1993). Amino acids in cerebrospinal and brain interstitial fluid in experimental pneumococcal meningitis. Pediatric research, 33(5), pp. 510-3. New York, N.Y.: Nature Publishing Group 10.1203/00006450-199305000-00018

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Excitatory amino acids are increasingly implicated in the pathogenesis of neuronal injury induced by a variety of CNS insults, such as ischemia, trauma, hypoglycemia, and epilepsy. Little is known about the role of amino acids in causing CNS injury in bacterial meningitis. Several amino acids were measured in cerebrospinal fluid and in microdialysis samples from the interstitial fluid of the frontal cortex in a rabbit model of pneumococcal meningitis. Cerebrospinal fluid concentrations of glutamate, aspartate, glycine, taurine, and alanine increased significantly in infected animals. Among the amino acids with known excitatory or inhibitory function, interstitial fluid concentrations of glutamate were significantly elevated (by 470%). Alanine, a marker for anaerobic glycolysis, also increased in the cortex of infected rabbits. The elevated glutamate concentrations in the brain extracellular space suggest that excitotoxic neuronal injury may play a role in bacterial meningitis.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Täuber, Martin G.






Nature Publishing Group




Factscience Import

Date Deposited:

04 Oct 2013 15:00

Last Modified:

04 May 2014 23:17

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Web of Science ID:


URI: (FactScience: 60953)

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