Toxicity in neuronal cells caused by cerebrospinal fluid from pneumococcal and gram-negative meningitis

Täuber, MG; Sachdeva, M; Kennedy, SL; Loetscher, H; Lesslauer, W (1992). Toxicity in neuronal cells caused by cerebrospinal fluid from pneumococcal and gram-negative meningitis. Journal of infectious diseases, 166(5), pp. 1045-50. Cary, N.C.: Oxford University Press 10.1093/infdis/166.5.1045

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To identify neurotoxic factors in meningitis, a neuronal cell line (HN33.1) was exposed to cerebrospinal fluid (CSF) obtained from rabbits with pneumococcal meningitis or Escherichia coli meningitis or 2 h and 6 h after meningitis was induced by proinflammatory bacterial products (pneumococcal cell walls, endotoxin). CSF from all types of meningitis induced similar degrees of cytotoxicity. When a soluble tumor necrosis factor (TNF) receptor that completely blocked TNF-mediated toxicity at 10(-7) M was used, all toxicity in meningitis caused by E. coli, endotoxin, or pneumococcal cell wall administration (2 h afterwards) was mediated by TNF. In contrast, CSF from animals with meningitis caused by live pneumococci or pneumococcal cell wall injection (6 h afterwards) retained cytotoxicity in the presence of the TNF receptor. Thus, in established pneumococcal meningitis, but not in the other forms of meningitis, TNF is not the only component toxic in this neuronal cell line.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Täuber, Martin G.

ISSN:

0022-1899

ISBN:

1402015

Publisher:

Oxford University Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:00

Last Modified:

04 May 2014 23:17

Publisher DOI:

10.1093/infdis/166.5.1045

PubMed ID:

1402015

Web of Science ID:

A1992JV01500013

URI:

https://boris.unibe.ch/id/eprint/25794 (FactScience: 60958)

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