Differences of pathophysiology in experimental meningitis caused by three strains of Streptococcus pneumoniae

Täuber, MG; Burroughs, M; Niemöller, UM; Kuster, H; Borschberg, U; Tuomanen, E (1991). Differences of pathophysiology in experimental meningitis caused by three strains of Streptococcus pneumoniae. Journal of infectious diseases, 163(4), pp. 806-11. Cary, N.C.: Oxford University Press 10.1093/infdis/163.4.806

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Differences in cytochemical and pathophysiologic abnormalities in experimental meningitis caused by pneumococcal strains A, B, and C were determined. Strain C produced the most severe abnormalities of cerebrospinal fluid (CSF) concentrations of lactate (P less than .01), protein (P less than .02), and glucose (P less than .01), CSF white blood cell count (P less than .04), cerebral blood flow (P less than .02), and clinical signs (P less than .05). Brain edema occurred only with strains A anc C, with no association with disease severity; intracranial hypertension was also independent of disease severity. Strain B, not C, achieved the highest bacterial titers in the CSF (P less than .005). The widely different abilities of strains of Streptococcus pneumoniae to induce intracranial abnormalities suggest that virulence determinants affect not only evasion of defense during colonization and invasion, as shown in other models, but also determine the course of disease once infection has been established. Differences of cell-wall metabolism among pneumococcal strains may play a role in this latter phase of the development of meningitis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Täuber, Martin G.

ISSN:

0022-1899

ISBN:

1901331

Publisher:

Oxford University Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:00

Last Modified:

04 May 2014 23:17

Publisher DOI:

10.1093/infdis/163.4.806

PubMed ID:

1901331

Web of Science ID:

A1991FD93900021

URI:

https://boris.unibe.ch/id/eprint/25800 (FactScience: 60973)

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