Brain edema and increased intracranial pressure in the pathophysiology of bacterial meningitis

Niemöller, UM; Täuber, MG (1989). Brain edema and increased intracranial pressure in the pathophysiology of bacterial meningitis. European journal of clinical microbiology & infectious diseases, 8(2), pp. 109-17. Berlin: Springer 10.1007/BF01963892

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A number of advances in our understanding of the pathophysiology of bacterial meningitis have been made in recent years. In vivo studies have shown that bacterial cell wall fragments and endotoxins are highly active components, independent of the presence of viable bacteria in the subarachnoid space. Their presence in the cerebrospinal fluid is associated with the induction of inflammation and with the development of brain edema and increased intracranial pressure. Antimicrobial therapy may cause an additional increase of harmful bacterial products in the cerebrospinal fluid and thereby potentiate these pathophysiological alterations. These changes may contribute to the development of brain damage during meningitis. Some promising experimental work has been directed toward counteracting the above phenomena with non-steroidal or steroidal anti-inflammatory agents as well as with monoclonal antibodies. Although considerable advances have been made, further research needs to be done in these areas to improve the prognosis of bacterial meningitis.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Täuber, Martin G.

ISSN:

0934-9723

ISBN:

2498090

Publisher:

Springer

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:00

Last Modified:

04 May 2014 23:17

Publisher DOI:

10.1007/BF01963892

PubMed ID:

2498090

Web of Science ID:

A1989T501600001

URI:

https://boris.unibe.ch/id/eprint/25809 (FactScience: 60992)

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