Antimicrobial activity of gentamicin in experimental enterococcal endocarditis

Sullam, PM; Täuber, MG; Hackbarth, CJ; Sande, MA (1985). Antimicrobial activity of gentamicin in experimental enterococcal endocarditis. Antimicrobial agents and chemotherapy, 27(2), pp. 224-6. Washington, D.C.: American Society for Microbiology 10.1128/AAC.27.2.224

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The in vitro activity of gentamicin was compared with its therapeutic efficacy in rabbits with Streptococcus faecalis endocarditis. The test strain was resistant to gentamicin as measured by MICs and MBCs determined in Mueller-Hinton broth alone or in broth supplemented with 50% rabbit serum. Gentamicin also failed to manifest anti-enterococcal activity when evaluated by time-kill studies in broth. However, the addition of serum to the medium did enhance the activity of gentamicin. In the therapy of experimental endocarditis, gentamicin used alone demonstrated anti-enterococcal activity equivalent to that of ampicillin used alone. Vegetation titers in animals treated with gentamicin alone were lower than those of untreated controls (P less than 0.01) and comparable to those in animals treated with ampicillin alone. Thus, gentamicin demonstrated anti-enterococcal activity in vivo despite the resistance observed in vitro, as measured by conventional assays to determine MICs and MBCs.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Täuber, Martin G.

ISSN:

0066-4804

ISBN:

3920960

Publisher:

American Society for Microbiology

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:00

Last Modified:

04 May 2014 23:18

Publisher DOI:

10.1128/AAC.27.2.224

PubMed ID:

3920960

Web of Science ID:

A1985AKG2300017

URI:

https://boris.unibe.ch/id/eprint/25833 (FactScience: 61043)

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