The postantibiotic effect in the treatment of experimental meningitis caused by Streptococcus pneumoniae in rabbits

Täuber, MG; Zak, O; Scheld, WM; Hengstler, B; Sande, MA (1984). The postantibiotic effect in the treatment of experimental meningitis caused by Streptococcus pneumoniae in rabbits. Journal of infectious diseases, 149(4), pp. 575-83. Cary, N.C.: Oxford University Press 10.1093/infdis/149.4.575

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The relevance of a postantibiotic effect in the treatment of pneumococcal meningitis was evaluated in a rabbit model. After administration of a single intravenous bolus of ampicillin at various dosages, such an effect was observed in all animals. The duration of this effect in vivo (2.5-18 hr) was consistently longer than that in vitro (1-4.3 hr); however, in rabbits the postantibiotic effect was eliminated by the administration of intravenous plus intracisternal beta-lactamase. In an assessment of the potential therapeutic benefit of the postantibiotic effect, the efficacy to two regimens of treatment with different intervals between doses was compared. One group of animals received ampicillin every 4 hr and another every 12 hr. With sufficiently high doses, drug concentrations in cerebrospinal fluid exceeded the minimal bactericidal concentration for most of the 4-hr interval but for only about one-third of the 12-hr interval. The rate of cure was similar for the two regimens and approximated 100% when peak drug concentrations in cerebrospinal fluid exceeded the minimal bactericidal concentration by at least 10-fold.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Täuber, Martin G.

ISSN:

0022-1899

ISBN:

6609999

Publisher:

Oxford University Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:00

Last Modified:

04 May 2014 23:18

Publisher DOI:

10.1093/infdis/149.4.575

PubMed ID:

6609999

Web of Science ID:

A1984SQ28000015

URI:

https://boris.unibe.ch/id/eprint/25838 (FactScience: 61053)

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