Brain levels of neuropeptide Y in experimental pneumococcal meningitis

Täuber, MG; Ferriero, D; Kennedy, SL; Sheldon, RA; Guerra-Romero, L (1993). Brain levels of neuropeptide Y in experimental pneumococcal meningitis. Molecular and chemical neuropathology, 18(1-2), pp. 15-26. Clifton, N.J.: Humana Press

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Neuropeptide Y (NPY), which is found in high concentrations in several regions of the brain including nuclei of the brain stem and in nerve fibers surrounding cerebral vessels, has been proposed to play a role in regulating cerebral blood flow (CBF) and systemic vegetative functions. Since CBF is altered during meningitis, we examined whether NPY concentrations changed in various regions of the rabbit brain in response to experimental pneumococcal meningitis. Changes were most pronounced in the medulla, where NPY concentration increased threefold after 48 h of infection. Concomitantly, there was an increase in NPY immunoreactive fibers surrounding small vessels in the dorsolateral medulla, especially in the nucleus tractus solitarius. These results suggest that NPY may play a role in inducing some of the hemodynamic changes seen during pneumococcal meningitis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Täuber, Martin G.

ISSN:

1044-7393

ISBN:

8466588

Publisher:

Humana Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:00

Last Modified:

17 Mar 2015 22:10

PubMed ID:

8466588

Web of Science ID:

A1993KQ79100002

URI:

https://boris.unibe.ch/id/eprint/25841 (FactScience: 61059)

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