Vascular dysfunction and reduced circulating endothelial progenitor cells in young healthy UK South Asian men

Murphy, Cliona; Kanaganayagam, Gajen S; Jiang, Benyu; Chowienczyk, Philip J; Zbinden, Rainer; Saha, Mrinal; Rahman, Salman; Shah, Ajay M; Marber, Michael S; Kearney, Mark T (2007). Vascular dysfunction and reduced circulating endothelial progenitor cells in young healthy UK South Asian men. Arteriosclerosis, thrombosis, and vascular biology, 27(4), pp. 936-42. Philadelphia, Pa.: Lippincott Williams & Wilkins 10.1161/01.ATV.0000258788.11372.d0

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OBJECTIVES: The objective of this study was to examine determinants of excess coronary artery disease risk in UK South Asians, more prevalent in this population than UK Caucasians, by examining differences in risk factors, vascular function, and endothelial progenitor cells (EPCs). METHODS AND RESULTS: 24 South Asian and 25 Caucasian healthy age-matched nonsmoking men were studied. Vascular function was assessed by flow-mediated and GTN brachial artery dilatation and blood flow responses to infusion of ACh, SNP, and L-NMMA. EPC number and function were measured by flow cytometry (CD34, CD133, and KDR positive cells), and CFU/migration assays. Traditional risk factors and anthropometric measurements were similar in the groups. South Asians had higher fasting insulin levels (6.01 versus 3.62 microU/mL; P = 0.02). South Asians had lower FMD (6.9 versus 8.5%; P = 0.003), L-NMMA response (0.8 versus 1.3 mL/min/100 mL; P = 0.03), mean SNP response (9.5+/-0.6 versus 11.6+/-0.6; P = 0.02), EPC number (0.046+/-0.005% versus 0.085+/-0.009%; P = < 0.001), and CFU ability (CFU 4.29+/-1.57 versus 18.86+/-4.00; P = 0.005). EPC number was the strongest predictor of FMD. Ethnicity was the strongest predictor of EPC number. CONCLUSIONS: Healthy South Asian men are more insulin resistant, and demonstrate endothelial dysfunction and reduced EPC number and function compared with Caucasians. These abnormalities may contribute to their increased CAD risk.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
UniBE Contributor:	Zbinden, Rainer
ISSN:	1079-5642
ISBN:	17255539
Publisher:	Lippincott Williams & Wilkins
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:00
Last Modified:	05 Dec 2022 14:18
Publisher DOI:	10.1161/01.ATV.0000258788.11372.d0
PubMed ID:	17255539
Web of Science ID:	000245104100037
URI:	https://boris.unibe.ch/id/eprint/26156 (FactScience: 65986)