Spectroscopic properties of pyrene-containing DNA mimics

Samain, Florent; Malinovskii, Vladimir L; Langenegger, Simon; Häner, Robert (2008). Spectroscopic properties of pyrene-containing DNA mimics. Bioorganic & medicinal chemistry, 16(1), pp. 27-33. Amsterdam: Elsevier 10.1016/j.bmc.2007.04.052

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DNA mimics containing non-nucleosidic pyrene building blocks are described. The modified oligomers form stable hybrids, although a slight reduction in hybrid stability is observed in comparison to the unmodified DNA duplex. The nature of the interaction between the pyrene residues in single and double stranded oligomers is analyzed spectroscopically. Intra- and inter-strand stacking interactions of pyrenes are monitored by UV-absorbance as well as fluorescence spectroscopy. Excimer formation is observed in both single and double strands. In general, intrastrand excimers show fluorescence emission at shorter wavelengths (approx. 5-10 nm) than excimers formed by interstrand interactions. The existence of two different forms of excimers (intra- vs. interstrand) is also revealed in temperature dependent UV-absorbance spectra. (C) 2007 Elsevier Ltd. All rights reserved.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

UniBE Contributor:

Samain, Florent; Langenegger, Simon Matthias and Häner, Robert

ISSN:

0968-0896

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:01

Last Modified:

06 Dec 2013 13:51

Publisher DOI:

10.1016/j.bmc.2007.04.052

Web of Science ID:

000253345400003

URI:

https://boris.unibe.ch/id/eprint/26212 (FactScience: 67148)

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