Effect of varying injection rates of a saline chaser on aortic enhancement in CT angiography: phantom study

Schindera, Sebastian T; Nelson, Rendon C; Howle, Laurens; Nichols, Eli; DeLong, David M; Merkle, Elmar M (2008). Effect of varying injection rates of a saline chaser on aortic enhancement in CT angiography: phantom study. European radiology, 18(8), pp. 1683-9. Berlin: Springer-Verlag 10.1007/s00330-008-0911-3

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The effect of varying injection rates of a saline chaser on aortic enhancement in computed tomography (CT) angiography was determined. Single-level, dynamic CT images of a physiological flow phantom were acquired between 0 and 50 s after initiation of contrast medium injection. Four injection protocols were applied with identical contrast medium administration (150 ml injected at 5 ml/s). For baseline protocol A, no saline chaser was applied. For protocols B, C, and D, 50 ml of saline was injected at 2.5 ml/s, 5 ml/s, and 10 ml/s, respectively. Injecting the saline chaser at twice the rate as the contrast medium yielded significantly higher peak aortic enhancement values than injecting the saline at half or at the same rate as the contrast medium (P < 0.05). Average peak aortic enhancement (HU) measured 214, 214, 218, and 226 for protocols A, B, C, and D, respectively. The slower the saline-chaser injection rate, the longer the duration of 90% peak enhancement: 13.6, 12.2, and 11.7 s for protocols B, C, and D, respectively (P > 0.05). In CT angiography, saline chaser injected at twice the rate as the contrast medium leads to increased peak aortic enhancement and saline chaser injected at half the rate tends towards prolonging peak aortic enhancement plateau.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Schindera, Sebastian Tobias

ISSN:

0938-7994

ISBN:

18351346

Publisher:

Springer-Verlag

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:01

Last Modified:

26 Jun 2018 13:16

Publisher DOI:

10.1007/s00330-008-0911-3

PubMed ID:

18351346

Web of Science ID:

000257440700018

BORIS DOI:

10.7892/boris.26265

URI:

https://boris.unibe.ch/id/eprint/26265 (FactScience: 67973)

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