Ubiquitylation and SUMOylation of Cardiac Ion Channels

Rougier, Jean-Sébastien; Albesa, Maxime; Abriel, Hugues (2010). Ubiquitylation and SUMOylation of Cardiac Ion Channels. Journal of cardiovascular pharmacology, 56(1), pp. 22-28. Hagerstown, Md.: Wolters Kluwer Lippincott Williams & Wilkins 10.1097/FJC.0b013e3181daaff9

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Cardiac ion channels play an essential role in the generation of the action potential of cardiomyocytes. Over the past 15 years, a new field of research called channelopathies has emerged; it regroups all diseases caused by ion channel dysfunction. Investigators have largely determined the physiological roles of cardiac ion channels, but little is known about the molecular determinants of their regulation. Two post-translational mechanisms that are crucial in determining the fate of proteins are ubiquitylation and the SUMOylation pathways, which lead to the degradation and/or regulation of modified proteins. Recently, several groups have investigated the physiological impacts of these mechanisms on the regulation of different classes of cardiac ion channels. The objective of this review is to summarize and briefly discuss these results.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Ionenkanalkrankheiten
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Ionenkanalkrankheiten

UniBE Contributor:

Rougier, Jean-Sébastien; Albesa, Maxime and Abriel, Hugues

ISSN:

0160-2446

Publisher:

Wolters Kluwer Lippincott Williams & Wilkins

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:07

Last Modified:

08 Jun 2016 10:19

Publisher DOI:

10.1097/FJC.0b013e3181daaff9

PubMed ID:

20224423

Web of Science ID:

000280641400004

URI:

https://boris.unibe.ch/id/eprint/264 (FactScience: 197218)

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