Blood concentration curve of cyclosporine: impact of itraconazole in lung transplant recipients

Irani, Sarosh; Fattinger, Karin; Schmid-Mahler, Cornelia; Achermann, Eva; Speich, Rudolf; Boehler, Annette (2007). Blood concentration curve of cyclosporine: impact of itraconazole in lung transplant recipients. Transplantation, 83(8), pp. 1130-3. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/01.tp.0000259724.44008.9d

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Although the influence of cytochrome P450 inhibitory drugs on the area under the curve (AUC) of cyclosporine (CsA) has been described, data concerning the impact of these substances on the shape of the blood concentration curve are scarce. By assessment of CsA blood levels before and 1, 2, and 4 hr after oral intake (C0, C1, C2, and C4, respectively) CsA profiling examinations were performed in 20 lung transplant recipients taking 400 mg, 200 mg, and no itraconazole, respectively. The three groups showed comparable results for C0, C2, and AUC(0-12). Greater values were found for Cmax, Cmax-C0, peak-trough fluctuation and rise to Cmax in favor of the non-itraconazole group. Additionally, tmax was shorter in the non-itraconazole group. Comedication with the metabolic inhibitor itraconazole is associated with a flattening of the CsA blood concentration profile in lung transplant recipients. These changes cannot be assessed by isolated C0, C2, or AUC(0-12) values alone.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine > Centre of Competence for General Internal Medicine

UniBE Contributor:

Fattinger, Karin

ISSN:

0041-1337

ISBN:

17452906

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:01

Last Modified:

04 May 2014 23:18

Publisher DOI:

10.1097/01.tp.0000259724.44008.9d

PubMed ID:

17452906

Web of Science ID:

000246234800020

URI:

https://boris.unibe.ch/id/eprint/26434 (FactScience: 70876)

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