Caspase-3-independent photoreceptor degeneration by N-methyl-N-nitrosourea (MNU) induces morphological and functional changes in the mouse retina

Zulliger, Rahel; Lecaudé, Stéphanie; Eigeldinger-Berthou, Sylvie; Wolf-Schnurrbusch, Ute; Enzmann, Volker (2011). Caspase-3-independent photoreceptor degeneration by N-methyl-N-nitrosourea (MNU) induces morphological and functional changes in the mouse retina. Graefe's archive for clinical and experimental ophthalmology, 249(6), pp. 859-869. Berlin: Springer-Verlag 10.1007/s00417-010-1584-6

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Retinal degeneration is followed by significant changes in the structure and function of photoreceptors in humans and several genetic animal models. However, it is not clear whether similar changes occur when the degeneration is induced pharmacologically. Therefore, our aim was to investigate the influence of retinotoxic N-methyl-N-nitrosourea (MNU) on the function, morphology and underlying molecular pathways of programmed cell death.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Lecaudé, Stéphanie; Wolf-Schnurrbusch, Ute and Enzmann, Volker

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0721-832X

Publisher:

Springer-Verlag

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:12

Last Modified:

24 Oct 2019 20:48

Publisher DOI:

10.1007/s00417-010-1584-6

PubMed ID:

21240523

Web of Science ID:

000291166600010

BORIS DOI:

10.7892/boris.2644

URI:

https://boris.unibe.ch/id/eprint/2644 (FactScience: 205489)

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