White matter anisotropy related to electrophysiology of first episode schizophrenia during NoGo inhibition

Begré, Stefan; Kleinlogel, Horst; Kiefer, Claus; Strik, Werner; Dierks, Thomas; Federspiel, Andrea (2008). White matter anisotropy related to electrophysiology of first episode schizophrenia during NoGo inhibition. Neurobiology of disease, 30(2), pp. 270-80. Amsterdam: Elsevier 10.1016/j.nbd.2008.01.013

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Patients with schizophrenia have reduced execution functions and white matter alterations indicating cerebral disconnectivity. Here we investigated the relationship between white matter integrity and event related potentials (ERP) during a continuous performance test (CPT). Anisotropy values were correlated with the brain electrical P300 microstate duration and P300 latency associated to the NoGo- and the Go-stimuli of the CPT in 11 patients with first episode schizophrenia and 11 matched healthy controls. Both groups showed significant positive correlations of the NoGo-microstate duration with the white matter signal in the superior frontal region, the optic radiation, the posterior cingulate, and the inferolateral fascicle. In addition, patients with first episode schizophrenia had significant correlations with the right radiation and the left genu of the corpus callosum, bilateral geniculate, and the left middle and the superior temporal regions. We interpreted these findings as a sign of functional correlates of extended circuits for the active inhibition of a motor response in the visual CPT as compared to controls.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology > Centre of Competence for Psychosomatic Medicine
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Psychiatric Neurophysiology (discontinued)
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Management

UniBE Contributor:

Begré, Stefan; Kleinlogel, Horst; Kiefer, Claus; Strik, Werner; Dierks, Thomas and Federspiel, Andrea

ISSN:

0969-9961

ISBN:

18356066

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:01

Last Modified:

04 May 2014 23:18

Publisher DOI:

10.1016/j.nbd.2008.01.013

PubMed ID:

18356066

Web of Science ID:

000255718200012

URI:

https://boris.unibe.ch/id/eprint/26564 (FactScience: 73505)

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