Dimeric IVIG contains natural anti-Siglec-9 autoantibodies and their anti-idiotypes

Schaub, A; von Gunten, S; Vogel, M; Wymann, S; Rüegsegger, M; Stadler, B M; Spycher, M; Simon, H-U; Miescher, S (2011). Dimeric IVIG contains natural anti-Siglec-9 autoantibodies and their anti-idiotypes. Allergy, 66(8), pp. 1030-7. Oxford: Wiley-Blackwell 10.1111/j.1398-9995.2011.02579.x

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Intravenous immunoglobulin (IVIG) preparations are increasingly used for the treatment of autoimmune and chronic inflammatory diseases. Naturally occurring autoantibodies against Siglec-9 and Fas are thought to contribute to the anti-inflammatory effects of IVIG via cell death regulation of leukocytes and tissue cells. Dimeric IVIG fractions are suspected to contain idiotypic (Id)-anti-idiotypic complexes of antibodies, which might also include anti-Siglec-9 and anti-Fas autoantibodies.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute for Immunology (discontinued)
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

von Gunten, Stephan; Vogel, Monique; Rüegsegger, Michael; Stadler, Beda Martin and Simon, Hans-Uwe

ISSN:

0105-4538

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:12

Last Modified:

17 Mar 2015 19:15

Publisher DOI:

10.1111/j.1398-9995.2011.02579.x

PubMed ID:

21385183

Web of Science ID:

000292457700007

URI:

https://boris.unibe.ch/id/eprint/2665 (FactScience: 205511)

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