Postmortem whole-body CT angiography: evaluation of two contrast media solutions

Ross, Steffen; Spendlove, Danny; Bolliger, Stephan; Christe, Andreas; Oesterhelweg, Lars; Grabherr, Silke; Thali, Michael J; Gygax, Erich (2008). Postmortem whole-body CT angiography: evaluation of two contrast media solutions. AJR, American journal of roentgenology, 190(5), pp. 1380-9. Leesburg, Va.: American Roentgen Ray Society 10.2214/AJR.07.3082

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OBJECTIVE: The objective of our study was to establish a standardized procedure for postmortem whole-body CT-based angiography with lipophilic and hydrophilic contrast media solutions and to compare the results of these two methods. MATERIALS AND METHODS: Minimally invasive postmortem CT angiography was performed on 10 human cadavers via access to the femoral blood vessels. Separate perfusion of the arterial and venous systems was established with a modified heart-lung machine using a mixture of an oily contrast medium and paraffin (five cases) and a mixture of a water-soluble contrast medium with polyethylene glycol (PEG) 200 in the other five cases. Imaging was executed with an MDCT scanner. RESULTS: The minimally invasive femoral approach to the vascular system provided a good depiction of lesions of the complete vascular system down to the level of the small supplying vessels. Because of the enhancement of well-vascularized tissues, angiography with the PEG-mixed contrast medium allowed the detection of tissue lesions and the depiction of vascular abnormalities such as pulmonary embolisms or ruptures of the vessel wall. CONCLUSION: The angiographic method with a water-soluble contrast medium and PEG as a contrast-agent dissolver showed a clearly superior quality due to the lack of extravasation through the gastrointestinal vascular bed and the enhancement of soft tissues (cerebral cortex, myocardium, and parenchymal abdominal organs). The diagnostic possibilities of these findings in cases of antemortem ischemia of these tissues are not yet fully understood.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Legal Medicine > Forensic Medicine
04 Faculty of Medicine > Service Sector > Institute of Legal Medicine
04 Faculty of Medicine > Service Sector > Institute of Legal Medicine > Management
04 Faculty of Medicine > Service Sector > Institute of Legal Medicine > Forensic Imaging
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Ross, Steffen; Spendlove, Danny; Bolliger, Stephan; Christe, Andreas and Thali, Michael

ISSN:

0361-803X

ISBN:

18430859

Publisher:

American Roentgen Ray Society

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:01

Last Modified:

24 Jul 2014 15:06

Publisher DOI:

10.2214/AJR.07.3082

PubMed ID:

18430859

Web of Science ID:

000255185100041

URI:

https://boris.unibe.ch/id/eprint/26652 (FactScience: 80275)

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