Strengthening of laterality of verbal and visuospatial functions during childhood and adolescence

Everts, Regula; Lidzba, Karen; Wilke, Marko; Kiefer, Claus; Mordasini, Michela; Schroth, Gerhard; Perrig, Walter J.; Steinlin, Maja (2009). Strengthening of laterality of verbal and visuospatial functions during childhood and adolescence. Human brain mapping, 30(2), pp. 473-483. Hoboken, N.J.: Wiley-Blackwell 10.1002/hbm.20523

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Cognitive functions in the child's brain develop in the context of complex adaptive processes, determined by genetic and environmental factors. Little is known about the cerebral representation of cognitive functions during development. In particular, knowledge about the development of right hemispheric (RH) functions is scarce. Considering the dynamics of brain development, localization and lateralization of cognitive functions must be expected to change with age. Twenty healthy subjects (8.6-20.5 years) were examined with fMRI and neuropsychological tests. All participants completed two fMRI tasks known to activate left hemispheric (LH) regions (language tasks) and two tasks known to involve predominantly RH areas (visual search tasks). A laterality index (LI) was computed to determine the asymmetry of activation. Group analysis revealed unilateral activation of the LH language circuitry during language tasks while visual search tasks induced a more widespread RH activation pattern in frontal, superior temporal, and occipital areas. Laterality of language increased between the ages of 8-20 in frontal (r = 0.392, P = 0.049) and temporal (r = 0.387, P = 0.051) areas. The asymmetry of visual search functions increased in frontal (r = -0.525, P = 0.009) and parietal (r = -0.439, P = 0.027) regions. A positive correlation was found between Verbal-IQ and the LI during a language task (r = 0.585, P = 0.028), while visuospatial skills correlated with LIs of visual search (r = -0.621, P = 0.018). To summarize, cognitive development is accompanied by changes in the functional representation of neuronal circuitries, with a strengthening of lateralization not only for LH but also for RH functions. Our data show that age and performance, independently, account for the increases of laterality with age.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Everts, Regula; Kiefer, Claus; Mordasini, Michela; Schroth, Gerhard and Steinlin, Maja

ISSN:

1065-9471

ISBN:

18219619

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:01

Last Modified:

11 Jul 2014 14:10

Publisher DOI:

10.1002/hbm.20523

PubMed ID:

18219619

Web of Science ID:

000263232800011

URI:

https://boris.unibe.ch/id/eprint/26685 (FactScience: 84230)

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