[Imaging diagostics of geographic atrophy]

Fleckenstein, M; Wolf-Schnurrbusch, U; Wolf, S; von Strachwitz, C; Holz, F G; Schmitz-Valckenberg, S (2010). [Imaging diagostics of geographic atrophy]. Ophthalmologe, 107(11), pp. 1007-15. Heidelberg: Springer-Medizin-Verlag 10.1007/s00347-010-2159-y

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The development of imaging technologies has contributed to the understanding of the genesis and pathophysiological mechanisms of geographic atrophy (GA) secondary to age-related macular degeneration (AMD). Fundus autofluorescence (FAF) imaging allows accurate discrimination of the boundaries of atrophic patches. Furthermore, predictive markers for disease progression can be identified. Non-invasive FAF imaging now represents the gold standard for evaluating progressive enlargement of atrophic areas. By means of high resolution optical coherence tomography (OCT) microstructural retinal changes in GA can be identified. Anatomical endpoints are now being used in interventional GA trials and represent meaningful outcome parameters as surrogate markers in an overall slowly progressive disease which may not affect the fovea until later stages of the disease.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Wolf-Schnurrbusch, Ute

ISSN:

0941-293X

Publisher:

Springer-Medizin-Verlag

Language:

German

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:12

Last Modified:

17 Mar 2015 19:15

Publisher DOI:

10.1007/s00347-010-2159-y

PubMed ID:

21088949

Web of Science ID:

000284425600003

URI:

https://boris.unibe.ch/id/eprint/2670 (FactScience: 205518)

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