Potential of chemically modified hydrophilic surface characteristics to support tissue integration of titanium dental implants

Schwarz, Frank; Wieland, Marco; Schwartz, Zvi; Zhao, Ge; Rupp, Frank; Geis-Gerstorfer, Jürgen; Schedle, Andreas; Broggini, Nina; Bornstein, Michael M; Buser, Daniel; Ferguson, Stephen J; Becker, Jürgen; Boyan, Barbara D; Cochran, David L (2009). Potential of chemically modified hydrophilic surface characteristics to support tissue integration of titanium dental implants. Journal of biomedical materials research. Part B - applied biomaterials, 88(2), pp. 544-57. Hoboken, N.J.: John Wiley & Sons 10.1002/jbm.b.31233

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In the past, several modifications of specific surface properties such as topography, structure, chemistry, surface charge, and wettability have been investigated to predictably improve the osseointegration of titanium implants. The aim of the present review was to evaluate, based on the currently available evidence, the impact of hydrophilic surface modifications of titanium for dental implants. A surface treatment was performed to produce hydroxylated/hydrated titanium surfaces with identical microstructure to either acid-etched, or sand-blasted, large grit and acid-etched substrates, but with hydrophilic character. Preliminary in vitro studies have indicated that the specific properties noted for hydrophilic titanium surfaces have a significant influence on cell differentiation and growth factor production. Animal experiments have pointed out that hydrophilic surfaces improve early stages of soft tissue and hard tissue integration of either nonsubmerged or submerged titanium implants. This data was also corroborated by the results from preliminary clinical studies. In conclusion, the present review has pointed to a potential of hydrophilic surface modifications to support tissue integration of titanium dental implants.

Item Type:

Journal Article (Further Contribution)


04 Faculty of Medicine > School of Dental Medicine > Department of Oral Surgery and Stomatology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute for Surgical Technology & Biomechanics ISTB [discontinued]

UniBE Contributor:

Broggini, Nina, Bornstein, Michael, Buser, Daniel Albin, Ferguson, Stephen John




John Wiley & Sons




Eveline Carmen Schuler

Date Deposited:

04 Oct 2013 15:02

Last Modified:

02 Mar 2023 23:22

Publisher DOI:


PubMed ID:


Web of Science ID:



https://boris.unibe.ch/id/eprint/26753 (FactScience: 87919)

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