Association of the composite IL-1 genotype with peri-implantitis: a systematic review

Huynh Ba, Guy; Lang, N P; Tonetti, Maurizio; Zwahlen, Marcel; Salvi, Giovanni (2008). Association of the composite IL-1 genotype with peri-implantitis: a systematic review. Clinical oral implants research, 19(11), pp. 1154-1162. Oxford: Wiley-Blackwell 10.1111/j.1600-0501.2008.01596.x

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OBJECTIVE: Cytokine gene polymorphisms may modulate the host response to the bacterial challenge and influence susceptibility to peri-implantitis. OBJECTIVE: To systematically review the evidence of an association between the interleukin-1 (IL-1) composite genotype, i.e. presence of the allele 2 in the gene clusters IL-1A (-889) and in IL-1B (+3953), and peri-implantitis. MATERIAL AND METHODS: An electronic search in the National Library of Medicine-computerized bibliographic database MEDLINE and a manual search were performed. The search was conducted for longitudinal clinical trials comparing progression of peri-implantitis in IL-1 genotype positive (carrying allele 2) with IL-1 genotype negative (not carrying allele 2) subjects. Selection of publications, extraction of data and validity assessment were made independently by two reviewers. RESULTS: The search provided 44 titles of which two longitudinal publications were included. CONCLUSION: Based on the findings from this study, there is not enough evidence to support or refute an association between the IL-1 genotype status and peri-implantitis. Systematic genetic testing for the assessment of the risk of peri-implantitis cannot be recommended as a standard of care at this time.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)
04 Faculty of Medicine > School of Dental Medicine > Division of Fixed Prosthodontics [discontinued]

UniBE Contributor:

Huynh Ba, Guy; Lang, Niklaus Peter; Tonetti, Maurizio; Zwahlen, Marcel and Salvi, Giovanni


600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services








Eveline Carmen Schuler

Date Deposited:

04 Oct 2013 15:02

Last Modified:

25 Jan 2017 12:16

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URI: (FactScience: 87959)

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