Abciximab for thrombolysis during intracranial aneurysm coiling

Gralla, Jan; Rennie, Adam T M; Corkill, Rufus A; Lalloo, Shivendra T; Molyneux, Andrew; Byrne, James V; Kuker, Wilhem (2008). Abciximab for thrombolysis during intracranial aneurysm coiling. Neuroradiology, 50(12), pp. 1041-7. Berlin: Springer-Verlag 10.1007/s00234-008-0457-8

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INTRODUCTION: Thrombotic events are a common and severe complication of endovascular aneurysm treatment with significant impact on patients' outcome. This study evaluates risk factors for thrombus formation and assesses the efficacy and safety of abciximab for clot dissolution. MATERIALS AND METHODS: All patients treated with abciximab during (41 patients) or shortly after (22 patients) intracranial aneurysm coil embolisation were retrieved from the institutional database (2000 to 2007, 1,250 patients). Sixty-three patients (mean age, 55.3 years, +/-12.8) had received either intra-arterial or intravenous abciximab. Risk factors for clot formation were assessed and the angiographic and clinical outcome evaluated. RESULTS: No aneurysm rupture occurred during or after abciximab application. The intra-procedural rate of total recanalisation was 68.3%. Thromboembolic complications were frequently found in aneurysms of the Acom complex and of the basilar artery, whilst internal carotid artery aneurysms were underrepresented. Two patients died of treatment-related intracranial haemorrhages into preexisting cerebral infarcts. Two patients developed a symptomatic groin haematoma. CONCLUSIONS: Abciximab is efficacious and safe for thrombolysis during and after endovascular intracranial aneurysm treatment in the absence of preexisting ischaemic stroke.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Gralla, Jan

ISSN:

0028-3940

ISBN:

18807025

Publisher:

Springer-Verlag

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:02

Last Modified:

26 Jun 2018 13:51

Publisher DOI:

10.1007/s00234-008-0457-8

PubMed ID:

18807025

Web of Science ID:

000261791300007

BORIS DOI:

10.7892/boris.26790

URI:

https://boris.unibe.ch/id/eprint/26790 (FactScience: 88227)

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