Down-regulation of porin M35 in Moraxella catarrhalis by aminopenicillins and environmental factors and its potential contribution to the mechanism of resistance to aminopenicillins

Jetter, Marion; Spaniol, Violeta; Troller, Rolf; Aebi, Christoph (2010). Down-regulation of porin M35 in Moraxella catarrhalis by aminopenicillins and environmental factors and its potential contribution to the mechanism of resistance to aminopenicillins. Journal of antimicrobial chemotherapy, 65(10), pp. 2089-96. Oxford: Oxford University Press 10.1093/jac/dkq312

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The outer membrane protein M35 of Moraxella catarrhalis is an antigenically conserved porin. Knocking out M35 significantly increases the MICs of aminopenicillins. The aim of this study was to determine the biological mechanism of this potentially new antimicrobial resistance mechanism of M. catarrhalis and the behaviour of M35 in general stress situations.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Jetter, Marion; Spaniol, Violeta; Troller, Rolf and Aebi, Christoph

ISSN:

0305-7453

Publisher:

Oxford University Press

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:12

Last Modified:

26 Oct 2019 11:47

Publisher DOI:

10.1093/jac/dkq312

PubMed ID:

20801781

Web of Science ID:

000282174800005

BORIS DOI:

10.7892/boris.2680

URI:

https://boris.unibe.ch/id/eprint/2680 (FactScience: 205545)

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