Tracking the transcriptional host response from the acute to the regenerative phase of experimental pneumococcal meningitis

Wittwer, Matthias; Grandgirard, Denis; Rohrbach, Janine; Leib, Stephen L. (2010). Tracking the transcriptional host response from the acute to the regenerative phase of experimental pneumococcal meningitis. BMC infectious diseases, 10(176), p. 176. London: BioMed Central 10.1186/1471-2334-10-176

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Despite the availability of effective antibiotic therapies, pneumococcal meningitis (PM) has a case fatality rate of up to 30% and causes neurological sequelae in up to half of the surviving patients. The underlying brain damage includes apoptosis of neurons in the hippocampus and necrosis in the cortex. Therapeutic options to reduce acute injury and to improve outcome from PM are severely limited.With the aim to develop new therapies a number of pharmacologic interventions have been evaluated. However, the often unpredictable outcome of interventional studies suggests that the current concept of the pathophysiologic events during bacterial meningitis is fragmentary. The aim of this work is to describe the transcriptomic changes underlying the complex mechanisms of the host response to pneumococcal meningitis in a temporal and spatial context using a well characterized infant rat model.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases

UniBE Contributor:

Grandgirard, Denis; Rohrbach, Janine and Leib, Stephen

ISSN:

1471-2334

Publisher:

BioMed Central

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:12

Last Modified:

28 Nov 2020 02:19

Publisher DOI:

10.1186/1471-2334-10-176

PubMed ID:

20565785

Web of Science ID:

000283134600001

BORIS DOI:

10.7892/boris.2684

URI:

https://boris.unibe.ch/id/eprint/2684 (FactScience: 205550)

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