Significantly shorter telomeres in T-cells of patients with ZAP-70+/CD38+ chronic lymphocytic leukaemia

Röth, Alexander; de Beer, Dirk; Nückel, Holger; Sellmann, Ludger; Dührsen, Ulrich; Dürig, Jan; Baerlocher, Gabriela M (2008). Significantly shorter telomeres in T-cells of patients with ZAP-70+/CD38+ chronic lymphocytic leukaemia. British journal of haematology, 143(3), pp. 383-6. Oxford: Wiley-Blackwell 10.1111/j.1365-2141.2008.07363.x

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In contrast to other B-cell neoplasias, chronic lymphocytic leukaemia (CLL) is characterized by increased non-leukaemic T-cells. In order to assess their replicative history, telomere length was analyzed in subsets of leucocytes from CLL patients. Naive and memory T-cells from ZAP-70(+)/CD38(+) patients exhibited significantly shorter average telomere lengths than ZAP-70(-)/CD38(-) patients. Compared to the age-related percentiles of telomere length values from healthy individuals practically all values of the naive and memory T-cells from the ZAP-70(+)/CD38(+) CLL patients fell below the 50th percentile. This indicated an extensive expansion and a role for T-cells in ZAP-70(+)/CD38(+) CLL patients.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory
UniBE Contributor:	de Beer, Dirk, Baerlocher, Gabriela M.
ISSN:	0007-1048
ISBN:	18759763
Publisher:	Wiley-Blackwell
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:02
Last Modified:	05 Dec 2022 14:19
Publisher DOI:	10.1111/j.1365-2141.2008.07363.x
PubMed ID:	18759763
Web of Science ID:	000260117300010
URI:	https://boris.unibe.ch/id/eprint/26913 (FactScience: 97207)