Significantly shorter telomeres in T-cells of patients with ZAP-70+/CD38+ chronic lymphocytic leukaemia

Röth, Alexander; de Beer, Dirk; Nückel, Holger; Sellmann, Ludger; Dührsen, Ulrich; Dürig, Jan; Baerlocher, Gabriela M (2008). Significantly shorter telomeres in T-cells of patients with ZAP-70+/CD38+ chronic lymphocytic leukaemia. British journal of haematology, 143(3), pp. 383-6. Oxford: Wiley-Blackwell 10.1111/j.1365-2141.2008.07363.x

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In contrast to other B-cell neoplasias, chronic lymphocytic leukaemia (CLL) is characterized by increased non-leukaemic T-cells. In order to assess their replicative history, telomere length was analyzed in subsets of leucocytes from CLL patients. Naive and memory T-cells from ZAP-70(+)/CD38(+) patients exhibited significantly shorter average telomere lengths than ZAP-70(-)/CD38(-) patients. Compared to the age-related percentiles of telomere length values from healthy individuals practically all values of the naive and memory T-cells from the ZAP-70(+)/CD38(+) CLL patients fell below the 50th percentile. This indicated an extensive expansion and a role for T-cells in ZAP-70(+)/CD38(+) CLL patients.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory

UniBE Contributor:

de Beer, Dirk and Baerlocher, Gabriela M.

ISSN:

0007-1048

ISBN:

18759763

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:02

Last Modified:

04 May 2014 23:18

Publisher DOI:

10.1111/j.1365-2141.2008.07363.x

PubMed ID:

18759763

Web of Science ID:

000260117300010

URI:

https://boris.unibe.ch/id/eprint/26913 (FactScience: 97207)

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