Biosynthesis and expression of VE-cadherin is regulated by the PI3K/mTOR signaling pathway

Bieri, Michael; Oroszlan, Melinda; Zuppinger, Christian; Mohacsi, Paul J (2009). Biosynthesis and expression of VE-cadherin is regulated by the PI3K/mTOR signaling pathway. Molecular immunology, 46(5), pp. 866-72. Amsterdam: Elsevier 10.1016/j.molimm.2008.09.011

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Vascular endothelial (VE)-cadherin is an essential protein of adherens junctions of endothelial cells and plays a pivotal role in vascular homeostasis. Mammalian target of rapamycin complex 2 (mTORC2) deficient mice display defects in fetal vascular development. Blocking mTOR or the upstream kinase phosphoinositide 3-kinase (PI3K) led to a dose-dependently decrease of the VE-cadherin mRNA and protein expression. Immunofluorescent staining showed a strongly decreased expression of VE-cadherin at the interface of human umbilical endothelial cells (HUVECs) followed by intercellular gap formation. Herewith, we demonstrated that the expression of VE-cadherin is dependent on mTOR and PI3K signaling.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
UniBE Contributor:	Oroszlan, Melinda, Zuppinger, Christian, Mohacsi, Paul
ISSN:	0161-5890
ISBN:	18990449
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 15:02
Last Modified:	05 Dec 2022 14:19
Publisher DOI:	10.1016/j.molimm.2008.09.011
PubMed ID:	18990449
Web of Science ID:	000263942200013
URI:	https://boris.unibe.ch/id/eprint/26990 (FactScience: 99381)