Biosynthesis and expression of VE-cadherin is regulated by the PI3K/mTOR signaling pathway

Bieri, Michael; Oroszlan, Melinda; Zuppinger, Christian; Mohacsi, Paul J (2009). Biosynthesis and expression of VE-cadherin is regulated by the PI3K/mTOR signaling pathway. Molecular immunology, 46(5), pp. 866-72. Amsterdam: Elsevier 10.1016/j.molimm.2008.09.011

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Vascular endothelial (VE)-cadherin is an essential protein of adherens junctions of endothelial cells and plays a pivotal role in vascular homeostasis. Mammalian target of rapamycin complex 2 (mTORC2) deficient mice display defects in fetal vascular development. Blocking mTOR or the upstream kinase phosphoinositide 3-kinase (PI3K) led to a dose-dependently decrease of the VE-cadherin mRNA and protein expression. Immunofluorescent staining showed a strongly decreased expression of VE-cadherin at the interface of human umbilical endothelial cells (HUVECs) followed by intercellular gap formation. Herewith, we demonstrated that the expression of VE-cadherin is dependent on mTOR and PI3K signaling.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Oroszlan, Melinda; Zuppinger, Christian and Mohacsi, Paul

ISSN:

0161-5890

ISBN:

18990449

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:02

Last Modified:

04 May 2014 23:18

Publisher DOI:

10.1016/j.molimm.2008.09.011

PubMed ID:

18990449

Web of Science ID:

000263942200013

URI:

https://boris.unibe.ch/id/eprint/26990 (FactScience: 99381)

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