H Fischer, Andreas; van der Loo, Bernd; M Shär, Gertrud; Zbinden, Reinhard; Duru, Firat; Brunckhorst, Corinna; Rousson, Valentin; Delacrétaz Y, Etienne; Stuber, Thomas; Oechslin, Erwin N; Follath, Ferenc; Jenni, Rolf (2008). Serological evidence for the association of Bartonella henselae infection with arrhythmogenic right ventricular cardiomyopathy. Clinical cardiology, 31(10), pp. 469-71. Hoboken, N.J.: Wiley 10.1002/clc.20269
Full text not available from this repository.BACKGROUND: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an important cause of sudden death in young adults. On the basis of histopathological findings its pathogenesis may involve both a genetic origin and an inflammatory process. Bartonella henselae may cause endomyocarditis and was detected in myocardium from a young male who succumbed to sudden cardiac death. HYPOTHESIS: We hypothesized that chronic infection with Bartonella henselae could contribute to the pathogenesis of ARVC. METHODS: We investigated sera from 49 patients with ARVC for IgG antibodies to Bartonella henselae. In this study, 58 Swiss blood donors tested by the same method served as controls. RESULTS: Six patients with ARVC (12%) had positive (>1:256) IgG titres in the immunofluorescence test with Bartonella henselae. In contrast, only 1 elevated titre was found in 58 controls (p < or = 0.05). Interestingly, all patients with increased titres had no familial occurrence of ARVC. CONCLUSIONS: Further studies in larger patient cohorts seem justified to investigate a possible causal link between chronic Bartonella henselae and ARVC, in particular its sporadic (nonfamilial) form.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology |
UniBE Contributor: |
Zbinden, Rainer |
ISSN: |
0160-9289 |
ISBN: |
18666174 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:02 |
Last Modified: |
05 Dec 2022 14:19 |
Publisher DOI: |
10.1002/clc.20269 |
PubMed ID: |
18666174 |
Web of Science ID: |
000260098000004 |
URI: |
https://boris.unibe.ch/id/eprint/27018 (FactScience: 99719) |
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