Serological evidence for the association of Bartonella henselae infection with arrhythmogenic right ventricular cardiomyopathy

H Fischer, Andreas; van der Loo, Bernd; M Shär, Gertrud; Zbinden, Reinhard; Duru, Firat; Brunckhorst, Corinna; Rousson, Valentin; Delacrétaz Y, Etienne; Stuber, Thomas; Oechslin, Erwin N; Follath, Ferenc; Jenni, Rolf (2008). Serological evidence for the association of Bartonella henselae infection with arrhythmogenic right ventricular cardiomyopathy. Clinical cardiology, 31(10), pp. 469-71. Hoboken, N.J.: Wiley 10.1002/clc.20269

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BACKGROUND: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an important cause of sudden death in young adults. On the basis of histopathological findings its pathogenesis may involve both a genetic origin and an inflammatory process. Bartonella henselae may cause endomyocarditis and was detected in myocardium from a young male who succumbed to sudden cardiac death. HYPOTHESIS: We hypothesized that chronic infection with Bartonella henselae could contribute to the pathogenesis of ARVC. METHODS: We investigated sera from 49 patients with ARVC for IgG antibodies to Bartonella henselae. In this study, 58 Swiss blood donors tested by the same method served as controls. RESULTS: Six patients with ARVC (12%) had positive (>1:256) IgG titres in the immunofluorescence test with Bartonella henselae. In contrast, only 1 elevated titre was found in 58 controls (p < or = 0.05). Interestingly, all patients with increased titres had no familial occurrence of ARVC. CONCLUSIONS: Further studies in larger patient cohorts seem justified to investigate a possible causal link between chronic Bartonella henselae and ARVC, in particular its sporadic (nonfamilial) form.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology

UniBE Contributor:

Zbinden, Rainer

ISSN:

0160-9289

ISBN:

18666174

Publisher:

Wiley

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:02

Last Modified:

04 May 2014 23:19

Publisher DOI:

10.1002/clc.20269

PubMed ID:

18666174

Web of Science ID:

000260098000004

URI:

https://boris.unibe.ch/id/eprint/27018 (FactScience: 99719)

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