Reubi, Jean-Claude; Maecke, Helmut R (2008). Peptide-based probes for cancer imaging. Journal of nuclear medicine, 49(11), pp. 1735-8. New York, N.Y.: Society of Nuclear Medicine 10.2967/jnumed.108.053041
Full text not available from this repository. (Request a copy)Receptors for regulatory peptides are overexpressed in a variety of human cancers. They represent the molecular basis for in vivo imaging with radiolabeled peptide probes. Somatostatin-derived tracers, designed to image the sst2-overexpressing neuroendocrine tumors, have enjoyed almost 2 decades of successful development and extensive clinical applications. More recent developments include second- and third-generation somatostatin analogs, with a broader receptor subtype profile or with antagonistic properties. Emerging tracers for other peptide receptors, including cholecystokinin/gastrin and GLP-1 analogs for neuroendocrine tumors, bombesin and neuropeptide-Y analogs for prostate or breast cancers, or Arg-Gly-Asp peptides for neoangiogenesis labeling, are also in current development. Application fields include both SPECT/CT and PET/CT.
Item Type: |
Journal Article (Further Contribution) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology |
UniBE Contributor: |
Reubi-Kattenbusch, Jean-Claude |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
0161-5505 |
ISBN: |
18927341 |
Publisher: |
Society of Nuclear Medicine |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:02 |
Last Modified: |
05 Dec 2022 14:19 |
Publisher DOI: |
10.2967/jnumed.108.053041 |
PubMed ID: |
18927341 |
Web of Science ID: |
000260846600007 |
URI: |
https://boris.unibe.ch/id/eprint/27057 (FactScience: 101609) |
Actions (login required)
 |
Edit item |