Peptide-based probes for cancer imaging

Reubi, Jean-Claude; Maecke, Helmut R (2008). Peptide-based probes for cancer imaging. Journal of nuclear medicine, 49(11), pp. 1735-8. New York, N.Y.: Society of Nuclear Medicine 10.2967/jnumed.108.053041

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Receptors for regulatory peptides are overexpressed in a variety of human cancers. They represent the molecular basis for in vivo imaging with radiolabeled peptide probes. Somatostatin-derived tracers, designed to image the sst2-overexpressing neuroendocrine tumors, have enjoyed almost 2 decades of successful development and extensive clinical applications. More recent developments include second- and third-generation somatostatin analogs, with a broader receptor subtype profile or with antagonistic properties. Emerging tracers for other peptide receptors, including cholecystokinin/gastrin and GLP-1 analogs for neuroendocrine tumors, bombesin and neuropeptide-Y analogs for prostate or breast cancers, or Arg-Gly-Asp peptides for neoangiogenesis labeling, are also in current development. Application fields include both SPECT/CT and PET/CT.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Reubi-Kattenbusch, Jean-Claude

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0161-5505

ISBN:

18927341

Publisher:

Society of Nuclear Medicine

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:02

Last Modified:

15 Oct 2019 11:33

Publisher DOI:

10.2967/jnumed.108.053041

PubMed ID:

18927341

Web of Science ID:

000260846600007

URI:

https://boris.unibe.ch/id/eprint/27057 (FactScience: 101609)

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