Dialysis and Renal Transplantation in HIV-Infected Patients: a European Survey

Trullas, Joan Carles; Mocroft, Amanda; Cofan, Federico; Tourret, Jérome; Moreno, Asunción; Bagnis, Corinne Isnard; Fux, Christoph Andreas; Katlama, Christine; Reiss, Peter; Lundgren, Jens; Gatell, Jose Maria; Kirk, Ole; Miró, Jose M; the EuroSIDA Investigators, (2010). Dialysis and Renal Transplantation in HIV-Infected Patients: a European Survey. Journal of acquired immune deficiency syndromes JAIDS, 55(5), pp. 582-589. Philadelphia, Pa.: Lippincott Williams & Wilkins 10.1097/QAI.0b013e3181efbe59

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OBJECTIVES:: To determine prevalence and characteristics of end-stage renal diseases (ESRD) [dialysis and renal transplantation (RT)] among European HIV-infected patients. METHODS:: Cross-sectional multicenter survey of EuroSIDA clinics during 2008. RESULTS:: Prevalence of ESRD was 0.5%. Of 122 patients with ESRD 96 were on dialysis and 26 had received a RT. Median age was 47 years, 73% were males and 43% were black. Median duration of HIV infection was 11 years. Thirty-three percent had prior AIDS; 91% were receiving antiretrovirals; and 88% had undetectable viral load. Median CD4T-cell count was 341 cells per cubic millimetre; 20.5% had hepatitis C coinfection. Most frequent causes of ESRD were HIV-associated nephropathy (46%) and other glomerulonephritis (28%). Hemodialysis (93%) was the most common dialysis modality; 34% of patients were on the RT waiting list. A poor HIV control was the reason for exclusion from RT waiting list in 22.4% of cases. All the RT recipients were all alive at the time of the survey. Acute rejection was reported in 8 patients (30%). Functioning graft was present in 21 (80%). CONCLUSIONS:: This is the first multinational cross-sectional study of ESRD among European HIV population. Low prevalence of ESRD was found. Two-thirds of patients were excluded from RT for non-HIV/AIDS-related pathologies. Most patients had a functioning graft despite a high acute rejection rate.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology

UniBE Contributor:

Fux, Christoph Andreas

ISSN:

0894-9255

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:13

Last Modified:

08 Jun 2016 10:21

Publisher DOI:

10.1097/QAI.0b013e3181efbe59

PubMed ID:

20811290

Web of Science ID:

000284147500009

URI:

https://boris.unibe.ch/id/eprint/2713 (FactScience: 205581)

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