Anticipating antiport in P-type ATPases

Niggli, Verena; Sigel, Erwin (2008). Anticipating antiport in P-type ATPases. Trends in biochemical sciences, 33(4), pp. 156-60. Cambridge: Elsevier Current Trends 10.1016/j.tibs.2007.12.005

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Cation-transporting P-type ATPases show a high degree of structural and functional homology. Nevertheless, for many members of this large family, the molecular mechanism of transport is unclear; namely, whether transport is electrogenic or not and if countertransport is involved remains to be established. In a few well-studied cases such as the Na(+)-K(+)-ATPase, plasma membrane Ca(2+) ATPase (PMCA) and sarcoplasmic reticulum Ca(2+) ATPase (SERCA) countertransport has been clearly demonstrated. New data based on the crystal structure of SERCA now strongly indicate that countertransport could be mandatory for all P-type ATPases. This concept should be verified for other known and for all newly characterized P-type ATPases.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Niggli, Verena and Sigel, Erwin

ISSN:

0968-0004

ISBN:

18343670

Publisher:

Elsevier Current Trends

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:02

Last Modified:

04 May 2014 23:19

Publisher DOI:

10.1016/j.tibs.2007.12.005

PubMed ID:

18343670

Web of Science ID:

000255447900002

URI:

https://boris.unibe.ch/id/eprint/27139 (FactScience: 104443)

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