Treatment of intestinal and hepatic mucormycosis in an immunocompromized child

Lüer, Sonja; Berger, Steffen; Diepold, Miriam; Duppenthaler, Andrea; von Gunten, Michael; Mühlethaler, Konrad; Wolf, Rainer; Aebi, Christoph (2009). Treatment of intestinal and hepatic mucormycosis in an immunocompromized child. Pediatric blood & cancer, 52(7), pp. 872-4. Hoboken, N.J.: Wiley-Liss 10.1002/pbc.21918

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During ALL chemotherapy, a 4-year-old patient presented with febrile neutropenia and abdominal pain. Ultrasound examinations were repeatedly normal. Computerized tomography on day 7 demonstrated appendicitis and multiple hepatic foci identified as mucormycosis (Absidia corymbifera). Successful outcome was achieved by aggressive re-surgery, long-term antifungal therapy with serum level-monitored posaconazole, and recovery of neutrophil counts. Considering the interference of posaconazole with CYP3A4, vincristine was administered during 72 hr posaconazole windows. Pediatric intestinal mucormycosis, still associated with a >70% case-fatality rate, calls for early imaging and surgery to establish the diagnosis, reduce the fungal mass, and provide a rationale for using posaconazole.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Surgery
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Lüer, Sonja Christina; Berger, Steffen Michael; Diepold, Miriam; Duppenthaler, Andrea; von Gunten, Michael and Aebi, Christoph

ISSN:

1545-5009

ISBN:

19127570

Publisher:

Wiley-Liss

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:02

Last Modified:

04 May 2014 23:19

Publisher DOI:

10.1002/pbc.21918

PubMed ID:

19127570

Web of Science ID:

000265346100027

URI:

https://boris.unibe.ch/id/eprint/27153 (FactScience: 104796)

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