Fatal adenovirus hepatitis during maintenance therapy for childhood acute lymphoblastic leukemia

Steiner, Isabelle; Aebi, Christoph; Ridolfi Lüthy, Annette; Wagner, Bendicht; Leibundgut, Kurt (2008). Fatal adenovirus hepatitis during maintenance therapy for childhood acute lymphoblastic leukemia. Pediatric blood & cancer, 50(3), pp. 647-9. Hoboken, N.J.: Wiley-Liss 10.1002/pbc.21120

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Disseminated adenoviral infection with hepatitis is rare in children undergoing standard chemotherapy. We report on a 3(1/2)-year-old male with fatal adenovirus hepatitis receiving maintenance chemotherapy for acute lymphoblastic leukemia (ALL). Adenoviral hepatitis was proven by histology, viral culture, and PCR in a liver biopsy. Quantitative real-time PCR in the peripheral blood showed adenoviral DNA copy number >10(9)/ml. Despite aggressive supportive care and antiviral treatment with cidofovir, the patient died rapidly due to fulminant liver failure. Diagnostic and treatment options for adenovirus infection remain unsatisfactory for these patients. We propose suggestions for diagnosis and therapy.

Item Type:	Journal Article (Further Contribution)
Division/Institute:	04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
UniBE Contributor:	Steiner, Isabelle (A), Aebi, Christoph, Wagner, Bendicht Peter, Leibundgut, Kurt
ISSN:	1545-5009
ISBN:	17278117
Publisher:	Wiley-Liss
Language:	English
Submitter:	Anette van Dorland
Date Deposited:	04 Oct 2013 15:02
Last Modified:	29 Mar 2023 23:33
Publisher DOI:	10.1002/pbc.21120
PubMed ID:	17278117
Web of Science ID:	000252587300030
URI:	https://boris.unibe.ch/id/eprint/27158 (FactScience: 104806)