Intellectual outcome, motor skills and BMI of children with congenital hypothyroidism: a population-based study

Arenz, Stephan; Nennstiel-Ratzel, Uta; Wildner, Manfred; Dörr, Helmuth-Günther; von Kries, Rüdiger (2008). Intellectual outcome, motor skills and BMI of children with congenital hypothyroidism: a population-based study. Acta paediatrica, 97(4), pp. 447-50. Oslo: Wiley 10.1111/j.1651-2227.2008.00702.x

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AIM: To evaluate intellectual outcome, motor skills and anthropometric data of children with congenital hypothyroidism (CH). METHODS: Children with permanent CH who were born in 1999 in Bavaria were eligible for this prospective, population-based study. Cognitive performance was evaluated by the Kaufman Assessment Battery for Children and motor skills were assessed by the motor test, Motoriktest für vier-bis sechsjahrige Kinder (MOT) 4-6. RESULTS: Eighteen of 21 eligible children participated (86%). Median age of the children was 5.5 years (range 4.9-5.8). Treatment with levothyroxine was started after a median of 7.2 days (range 4-15) with a median dose of 12.0 microg/kg (range 7.2-17.0). Mean intelligence quotient (IQ) of the children was 100.4 (standard deviation [SD] 10.1): no children had IQ values below the normal range. Reactivity and speed of movement were significantly reduced in children with CH. Children with an initial thyroid-stimulating hormone (TSH) value of >200 mU/L performed significantly worse than children with TSH value of <or=200 mU/L (p=0.003). Children with CH had a significant increased risk for overweight (risk ratio [RR] 3.91, 95% confidence interval [CI] 1.22-11.75, p=0.005) compared to the Bavarian reference children. CONCLUSION: In this study, children with CH had an increased prevalence of overweight compared to reference data. Partially impaired motor skills could be shown, whereas the intellectual development was normal.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Arenz, Stephan

ISSN:

1651-2227

ISBN:

18331367

Publisher:

Wiley

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:03

Last Modified:

06 May 2015 14:21

Publisher DOI:

10.1111/j.1651-2227.2008.00702.x

PubMed ID:

18331367

Web of Science ID:

000254272000016

URI:

https://boris.unibe.ch/id/eprint/27168 (FactScience: 104840)

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