Sweat test in patients with glucose-6-phosphate-1-dehydrogenase deficiency

Casaulta, C; Stirnimann, A; Schoeni, M H; Barben, J (2008). Sweat test in patients with glucose-6-phosphate-1-dehydrogenase deficiency. Archives of disease in childhood, 93(10), pp. 878-9. London: BMJ Publishing Group 10.1136/adc.2007.132688

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BACKGROUND: A false-positive sweat test in patients with deficiency of glucose-6-phosphate-1-dehydrogenase (EC 1.1.1.49; G6PD) is repeatedly reported. METHODS: Sweat chloride or conductivity was measured in 11 patients with G6PD deficiency. RESULTS: Mean (SD) chloride level (n = 8, median age 9.2 years, range 1.9-48.5) was 18.8 (9.6 mmol/l) and, mean (SD) sodium level was 26.0 (10.0 mmol/l), respectively, and mean (SD) conductivity (n = 3, median age 6.6 years, range 1.9-40.5) was 34.3 (6.5 mmol/l). CONCLUSION: In sweat of 11 patients with G6PD deficiency we did not find any abnormality. The reason for alleged false-positive sweat test in patients with G6PD deficiency is not known and we were unable to identify any original reference. It appears that tables of putative false-positive sweat tests in several disease states have been directly "copied and pasted" from one paper or textbook to another without verifying the original literature, a phenomenon one can call "chain citation".

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
UniBE Contributor:	Casaulta, Carmen, Schöni, Martin Heinrich
ISSN:	0003-9888
ISBN:	18456694
Publisher:	BMJ Publishing Group
Language:	English
Submitter:	Anette van Dorland
Date Deposited:	04 Oct 2013 15:03
Last Modified:	02 Mar 2023 23:22
Publisher DOI:	10.1136/adc.2007.132688
PubMed ID:	18456694
Web of Science ID:	000259401700015
URI:	https://boris.unibe.ch/id/eprint/27181 (FactScience: 104892)