Fluctuation analysis of lung function as a predictor of long-term response to beta2-agonists

Thamrin, C; Stern, G; Strippoli, M-P F; Kuehni, C E; Suki, B; Taylor, D R; Frey, U (2009). Fluctuation analysis of lung function as a predictor of long-term response to beta2-agonists. European respiratory journal, 33(3), pp. 486-493. Sheffield, UK: European Respiratory Society 10.1183/09031936.00106208

Thamrin EurRespirJ 2008.pdf - Accepted Version
Available under License Publisher holds Copyright.

Download (186kB) | Preview
[img] Text
Thamrin EurRespirJ 2009.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (373kB) | Request a copy

The response to beta(2)-agonists differs between asthmatics and has been linked to subsequent adverse events, even death. Possible determinants include beta(2)-adrenoceptor genotype at position 16, lung function and airway hyperresponsiveness. Fluctuation analysis provides a simple parameter alpha measuring the complex correlation properties of day-to-day peak expiratory flow. The present study investigated whether alpha predicts clinical response to beta(2)-agonist treatment, taking into account other conventional predictors. Analysis was performed on previously published twice-daily peak expiratory flow measurements in 66 asthmatic adults over three 6-month randomised order treatment periods: placebo, salbutamol and salmeterol. Multiple linear regression was used to determine the association between alpha during the placebo period and response to treatment (change in the number of days with symptoms), taking into account other predictors namely beta(2)-adrenoceptor genotype, lung function and its variability, and airway hyperresponsiveness. The current authors found that alpha measured during the placebo period considerably improved the prediction of response to salmeterol treatment, taking into account genotype, lung function or its variability, or airway hyperresponsiveness. The present study provides further evidence that response to beta(2)-agonists is related to the time correlation properties of lung function in asthma. The current authors conclude that fluctuation analysis of lung function offers a novel predictor to identify patients who may respond well or poorly to treatment.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Thamrin, Cindy; Stern Meggers, Georgette; Strippoli, Marie-Pierre; Kühni, Claudia and Frey, Urs Peter






European Respiratory Society




Factscience Import

Date Deposited:

04 Oct 2013 15:03

Last Modified:

23 Jul 2015 11:07

Publisher DOI:


PubMed ID:


Web of Science ID:





https://boris.unibe.ch/id/eprint/27195 (FactScience: 104932)

Actions (login required)

Edit item Edit item
Provide Feedback