Mechanisms and regulation of epithelial Ca2+ absorption in health and disease

Suzuki, Yoshiro; Landowski, Christopher P; Hediger, Matthias A (2008). Mechanisms and regulation of epithelial Ca2+ absorption in health and disease. Annual review of physiology, 70, pp. 257-271. Palo Alto, Calif.: Annual Reviews Inc. 10.1146/annurev.physiol.69.031905.161003

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Ca2+ is essential for numerous physiological functions in our bodies. Therefore, its homeostasis is finely maintained through the coordination of intestinal absorption, renal reabsorption, and bone resorption. The Ca2+-selective epithelial channels TRPV5 and TRPV6 have been identified, and their physiological roles have been revealed: TRPV5 is important in final renal Ca2+ reabsorption, and TRPV6 has a key role in intestinal Ca2+ absorption. The TRPV5 knockout mice exhibit renal leak hypercalciuria and accordingly upregulate their intestinal TRPV6 expression to compensate for their negative Ca2+ balance. In contrast, despite their severe negative Ca2+ balance, TRPV6-null mice do not display any compensatory mechanism, thus resulting in secondary hyperparathyroidism. These results indicate that the genes for TRPV5 and TRPV6 are differentially regulated in human diseases associated with disturbed Ca2+ balance such as hypercalciuria, osteoporosis, and vitamin D-resistant rickets.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Hediger, Matthias

ISSN:

0066-4278

ISBN:

17850211

Publisher:

Annual Reviews Inc.

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:03

Last Modified:

05 Dec 2022 14:19

Publisher DOI:

10.1146/annurev.physiol.69.031905.161003

PubMed ID:

17850211

Web of Science ID:

000254489400012

URI:

https://boris.unibe.ch/id/eprint/27339 (FactScience: 106083)

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