Zbären, Peter; Zbären, Sibylle; Caversaccio, Marco D; Stauffer, Edouard (2008). Carcinoma ex pleomorphic adenoma: diagnostic difficulty and outcome. Otolaryngology - head and neck surgery, 138(5), pp. 601-5. Thousand Oaks, Calif.: Sage 10.1016/j.otohns.2008.01.013
Full text not available from this repository. (Request a copy)OBJECTIVE: To analyze a series of carcinoma ex pleomorphic adenoma (CXPA) and to assess the diagnostic difficulties. STUDY DESIGN: The clinical presentation of 24 CXPAs was compared with 300 pleomorphic adenomas (PAs). Furthermore, pathohistological findings and follow-up results of CXPAs were evaluated. RESULTS: Eight of 24 (33%) CXPAs versus 41 of 300 (14%) PAs were localized in the deep lobe (P < 0.05). Forty-two percent of CXPAs versus 6 percent of PAs, respectively, were greater than 4 cm (P < 0.05). The sensitivity in detecting CXPA by fine-needle aspiration cytology (FNAC) was 47 percent. The tumor was known to be malignant preoperatively in 10 (42%) patients. Six of 24 (25%) patients with CXPA developed a tumor recurrence. The overall 5-year survival rate of CXPA was 76 percent. CONCLUSION: CXPAs are difficult to identify preoperatively. FNAC has a low accuracy and sensitivity. CXPAs versus PAs are significantly more frequently localized in the deep lobe and are significantly greater in size.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT) 04 Faculty of Medicine > Service Sector > Institute of Pathology |
UniBE Contributor: |
Zbären, Peter, Caversaccio, Marco, Stauffer, Edouard Jean |
ISSN: |
0194-5998 |
ISBN: |
18439465 |
Publisher: |
Sage |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 15:03 |
Last Modified: |
05 Dec 2022 14:19 |
Publisher DOI: |
10.1016/j.otohns.2008.01.013 |
PubMed ID: |
18439465 |
Web of Science ID: |
000255434700011 |
URI: |
https://boris.unibe.ch/id/eprint/27366 (FactScience: 106647) |
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