Acute and late toxicity in prostate cancer patients treated by dose escalated intensity modulated radiation therapy and organ tracking

Ghadjar, Pirus; Vock, Jacqueline; Vetterli, Daniel; Manser, Peter; Bigler, Roland; Tille, Jan; Madlung, Axel; Behrensmeier, Frank; Mini, Roberto; Aebersold, Daniel M (2008). Acute and late toxicity in prostate cancer patients treated by dose escalated intensity modulated radiation therapy and organ tracking. Radiation oncology, 3, p. 35. London: BioMed Central 10.1186/1748-717X-3-35

[img]
Preview
Text
5.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (250kB) | Preview

BACKGROUND: To report acute and late toxicity in prostate cancer patients treated by dose escalated intensity-modulated radiation therapy (IMRT) and organ tracking. METHODS: From 06/2004 to 12/2005 39 men were treated by 80 Gy IMRT along with organ tracking. Median age was 69 years, risk of recurrence was low 18%, intermediate 21% and high in 61% patients. Hormone therapy (HT) was received by 74% of patients. Toxicity was scored according to the CTC scale version 3.0. Median follow-up (FU) was 29 months. RESULTS: Acute and maximal late grade 2 gastrointestinal (GI) toxicity was 3% and 8%, late grade 2 GI toxicity dropped to 0% at the end of FU. No acute or late grade 3 GI toxicity was observed. Grade 2 and 3 pre-treatment genitourinary (GU) morbidity (PGUM) was 20% and 5%. Acute and maximal late grade 2 GU toxicity was 56% and 28% and late grade 2 GU toxicity decreased to 15% of patients at the end of FU. Acute and maximal late grade 3 GU toxicity was 8% and 3%, respectively. Decreased late > or = grade 2 GU toxicity free survival was associated with higher age (P = .025), absence of HT (P = .016) and higher PGUM (P < .001). DISCUSSION: GI toxicity rates after IMRT and organ tracking are excellent, GU toxicity rates are strongly related to PGUM.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology > Medical Radiation Physics

UniBE Contributor:

Ghadjar, Pirus; Vock, Jacqueline Ruth; Vetterli, Daniel; Manser, Peter; Madlung, Axel; Behrensmeier, Frank; Mini, Roberto and Aebersold, Daniel

ISSN:

1748-717X

ISBN:

18937833

Publisher:

BioMed Central

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 15:03

Last Modified:

07 Dec 2014 11:16

Publisher DOI:

10.1186/1748-717X-3-35

PubMed ID:

18937833

Web of Science ID:

000262441300001

BORIS DOI:

10.7892/boris.27368

URI:

https://boris.unibe.ch/id/eprint/27368 (FactScience: 106826)

Actions (login required)

Edit item Edit item
Provide Feedback