Level of G protein-coupled receptor kinase-2 determines myocardial ischemia/reperfusion injury via pro- and anti-apoptotic mechanisms

Brinks, Henriette; Boucher, Matthieu; Gao, Erhe; Chuprun, J Kurt; Pesant, Stéphanie; Raake, Philip W; Huang, Z Maggie; Wang, Xiaoliang; Qiu, Gang; Gumpert, Anna; Harris, David M; Eckhart, Andrea D; Most, Patrick; Koch, Walter J (2010). Level of G protein-coupled receptor kinase-2 determines myocardial ischemia/reperfusion injury via pro- and anti-apoptotic mechanisms. Circulation research, 107(9), pp. 1140-9. Baltimore, Md.: Lippincott Williams & Wilkins 10.1161/CIRCRESAHA.110.221010

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Activation of prosurvival kinases and subsequent nitric oxide (NO) production by certain G protein-coupled receptors (GPCRs) protects myocardium in ischemia/reperfusion injury (I/R) models. GPCR signaling pathways are regulated by GPCR kinases (GRKs), and GRK2 has been shown to be a critical molecule in normal and pathological cardiac function.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery

UniBE Contributor:

Most, Henriette

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0009-7330

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:13

Last Modified:

15 Dec 2014 15:39

Publisher DOI:

10.1161/CIRCRESAHA.110.221010

PubMed ID:

20814022

Web of Science ID:

000283583400014

URI:

https://boris.unibe.ch/id/eprint/2748 (FactScience: 205622)

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